The final population consisted of 401 patients from seven ICUs. A competing risk Cox proportional hazard model was applied to test for the association of DS with two competing outcomes (death or discharge from the ICU) while adjusting for confounders. Retrospective cohort study on data derived from Italian ICUs during the first year of the COVID-19 epidemic. Here, we explore the association between a surrogate measure of dead space (DS) and early outcomes of mechanically ventilated patients admitted to Intensive Care Unit (ICU) because of COVID-19-associated ARDS. Physiologic dead space is a well-established independent predictor of death in patients with acute respiratory distress syndrome (ARDS).
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