They'd be great on Normal if you had the runes to up them but on Nightmare you are more likely to have an exceptional weapon for a runeword or a good rare. But they have the tendency to drop later in the game when they are not so useful. Weapons are more useful after upgrade because in the game damage matters more than defense and the upgrade is cheaper in runes - Ral + Sol compared to Tal + Shael for armors. In any case it is useful for your merc for Andy runs if you have space to store it. I once had a character that had good gear for all other resistances and Venom Ward fit right in. Interestingly Venom Ward can be useful as exceptional if your build can capitalize on +90 poison resistance.
The Ward is a decent shield if upgraded provided you have 110 strength and are not a paladin - then paladin shields can easily get better. Magefist and Chance Guards do not require upgrade but if you can afford one it doesn't hurt since those easily can be end game items. If you play a kick assassin and you are using any normal uniques you should upgrade because damage goes up with item quality. Goblin Toe and Tearhaunch boots get better defense, 70-100 instead of 30. Goldwrap is easily an end game item for some MF builds. Goldwrap and Nightsmoke belts are useful on their own but upgraded they have the maximum four slots. Check the base stats for normal/exceptional/elite items online first. Don't lock yourself out of an item that you are using. Just remember that an upgraded items goes up in quality level and requirements and that means you need higher level and stats to use it. Some of the items are great if you up them.
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